B 014 Osteoporose - osteoporosis

Bei einem gesunden Knochen findet ständig ein ausgeglichener Stoffwechsel zwischen Knochenabbau und Knochenaufbau statt. Bei der Osteoporose ist der Knochenaufbau und der Knochenabbau der Knochenmasse im Ungleichgewicht . Es wird mehr Knochenmasse durch Osteoklasten abgebaut, als von den Osteoblasten wieder aufegebaut wird. Osteoporosis is a disease of bone that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of proteins in bone is altered. Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in men. Trabecular bone is the sponge-like bone in the ends of long bones and vertebrae. Cortical bone is the hard outer shell of bones and the middle of long bones. Because osteoblasts and osteoclasts inhabit the surface of bones, trabecular bone is more active, more subject to bone turnover, to remodeling. Common osteoporotic fracture sites, the wrist, the hip and the spine, have a relatively high trabecular bone to cortical bone ratio. These areas rely on trabecular bone for strength, and therefore the intense remodeling causes these areas to degenerate most when the remodeling is imbalanced.

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